A fast hierarchical clustering algorithm for functional modules discovery in protein interaction networks


Min Li, Jian-xin Wang, Jian-er Chen, Yi Pan

School of Information Science and Engineering, Central South University, China


Software download:  HC-PIN



The original protein-protein interaction data was downloaded from DIP (http://dip.doe-mbi.ucla.edu/). Each interaction in the original protein interaction network is assigned a confidence score based on the logisticregression scheme. The final weighted protein interaction network used in this paper is given as Test.txt.



Additional files:

Additional file 1: Example for hierarchical organization of functional modules.

This file contains the hierarchical modules shown in Figure 2 which are identified by HC-PIN with different values of parameter .

Additional file 2: Supplementary Figure

This file contains a supplementary Figure which shows the reduction of hierarchical structure of biological process annotations for the hierarchical modules shown in Figure 2.